Born in Vittoria (Italy), Francesco Spampinato studied Musicology at the University of Bologna (DAMS - Music), graduating with a Master’s degree in 2001, including a thesis in Musical Semiotics (supervised by Professor Gino Stefani). He then went on to receive a Doctorate in Musicological Research from the University of Aix-en-Provence in 2006, supervised by Professor Bernard Vecchione. Thesis title: Debussy et l’imaginaire de la matière. Métaphorisation et corporéité dans l’expérience musicale (Debussy and the imagination of matter. Metaphorization and corporeality in musical experience). In 2008, he obtained a Master’s degree in “Music Therapy and Art Therapy in the Globality of Languages” from the University of Rome 2 Tor Vergata. In 2011, he obtained from the French National Ministry of Education the upper grade title as italian professor (“agrégation d'italien”). In 2017, he obtained the "Habilitation à diriger des recherches" at the University of Strasbourg on Théories et analyses de l'imaginaire musical.

From 2002 to 2010, he lectured in Musical Semiotics and Musical Psychology at the University of Aix-en-Provence. From 2004 to 2006, he was also a temporary lecturer and research assistant for Musical Philosophy and History of Music.

Between 2007 and 2010, he taught History of Music at the Music Conservatories in the Italian towns of Parma, Reggio Emilia and Trento, and Musical Psychology at the Music Conservatories in Monopoli and Cesena. Meanwhile, he also composed electronic music for radio and television. Between 2010 and 2011, he directed the choir of "St. Catherine of Siena" in Aix-en-Provence.

From 2007 to 2011, he has been an associate fellow at the Institute for Aesthetics, Arts and Technology (IDEAT), UMR n°8153 CNRS/Sorbonne (supervisor Costin Miereanu). He has spoken at international conferences in Rome, Bologna, Paris, Aix-en-Provence, San Marino, Montreal and Helsinki. He is working on the project “Science of Musical Language” as a member of the scientific and organisational committee for the SLM2 (Saint-Rémy-de-Provence, 2004), SLM3 (Bologna, 2006) and SLM4 (Trento, 2008) symposia. From 2012 to 2016, he collaborates with Geneva Emotion Music Lab (GEM),  Haute Ecole de Musique and University of Geneva. Since 2016 he is researcher at the University of Strasbourg: Labex GREAM (Groupe de Recherches Expérimentales sur l’Acte Musical) and ACCRA (Approches Contemporaines de la Création et de la Réflexion Artistiques, EA 3402).

Since 2001, he has published scientific works in specialist journals and collective works. In June 2008, his first work, entitled Les Métamorphoses du son. Matérialité imaginative de l’écoute musicale (Sound metamorphoses. Imaginative materiality and music listening), was published by L'Harmattan, Paris, including a preface by Professor Gino Stefani. In November 2008, the italian publishing house LIM published the work L'ascolto musicale: condotte, pratiche, grammatiche (Music listening: conducts, practices, grammars), which Francesco Spampinato  produced with Luca Marconi and Daniele Barbieri. In December 2008, LIM also published the volume Il Nuovo in musica. Estetiche tecnologie linguaggi (The New in Music. Aesthetics, languages, technologies), produced with Rossana Dalmonte. In January 2011, he published the work Debussy, poète des eaux. Métaphorisation et corporéité dans l’expérience musicale (Debussy, water poet. Metaphorization and corporeality in musical experience), including a preface by Professor Bernard Vecchione (L'Harmattan, Paris). In 2013, he produced with Grazia Giacco e Jean Vion-Dury a volume on musical memory: Jeux de mémoire(s): regards croisés sur la musique (Paris, L'Harmattan). In June 2015, he published the book Les incarnations du son. Les métaphores du geste dans l'écoute musicale (Sound embodiments. Metaphors of gesture in music listening, Paris, L'Harmattan). In September 2019, he published the book Musica a pelle. Immaginario tattile e Globalità dei Linguaggi (Mimesis, Milano).